KMID : 1140220140190010047
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´ëÇѾϿ¹¹æÇÐȸÁö 2014 Volume.19 No. 1 p.47 ~ p.55
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Correlations Among Endoscopic, Histologic and Serologic Diagnoses for the Assessment of Atrophic Gastritis
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Lee Ju-Yup
Kim Na-Young Lee Hye-Seung Oh Jane C. Kwon Yong-Hwan Choi Yoon-Jin Yoon Ki-Chul Hwang Jae-Jin Lee Hyun-Joo Lee Ae-Ra Jeong Yeon-Sang Jo Hyun-Jin Yoon Hyuk Shin Cheol-Min Park Young-Soo Lee Dong-Ho
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Abstract
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Background: Atrophic gastritis is a precancerous condition, which can be diagnosed by several methods. However, there is no consensus for the standard method. The aim of this study was to evaluate the correlations among endoscopic, histologic, and serologic findings for the diagnosis of atrophic gastritis.
Methods: From March 2003 to August 2013, a total of 2,558 subjects were enrolled. Endoscopic atrophic gastritis was graded by Kimura-Takemoto classification and histological atrophic gastritis was assessed by updated Sydney system. Serological assessment of atrophic gastritis was based on serum pepsinogen test.
Results: The serum pepsinogen I/II ratio showed a significant decreasing nature when the extent of atrophy increased (R2=0.837, P<0.001) and the cut-off value for distinguishing between presence and absence of endoscopic atrophic gastritis was 3.2. The serum pepsinogen I and pepsinogen I/II ratio were significantly lower when the histological atrophic gastritis progressed and the cut-off value was 3.0 for a diagnosis of histological atrophic gastritis. A significant correlation between endoscopic and histological atrophic gastritis was noted and the sensitivity and specificity of endoscopic diagnosis were 65.9% and 58.0% for antrum, 71.3% and 53.7% for corpus, respectively.
Conclusions: The endoscopic, histological, and serological atrophic gastritis showed relatively good correlations. However, as these three methods have a limitation, a multifactorial assessment might be needed to ameliorate the diagnostic accuracy of atrophic gastritis.
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KEYWORD
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Atrophic gastritis, Histology, Endoscopy, Pepsinogen
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